Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury.

Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.

Studies in the rat have pointed to a role for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of acute tubular necrosis. These studies used antibodies, which may have nonspecific effects. We report that renal ICAM-1 mRNA levels and systemic levels of the cytokines IL-1 and TNF-alpha increase 1 h after ischemia/ reperfusion in the mouse. We sought direct proof for a critical role ...

Intercellular Adhesion Molecule (ICAM)-1,

Intercellular Adhesion Molecule-1 Expression

Intercellular Adhesion Molecule-1 Deficiency

Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney.

Endogenous mechanisms exist to limit inflammation. One such molecule is netrin. This study examined the impact of ischemia-reperfusion (I/R) on netrin expression and the role of netrin in preventing renal inflammation and injury. All three isoforms of netrin (1, 3, and 4) are expressed in normal kidney. I/R significantly downregulated netrin-1 and -4 mRNA expression, whereas expression of netri...